Journal article
Body Mass Index, sex, non-steroidal anti-inflammatory drug medications, smoking and alcohol are differentially associated with World Health Organisation criteria and colorectal cancer risk in people with Serrated Polyposis Syndrome: an Australian case-control study
E Anthony, JC Reece, E Milanzi, JE Joo, S Joseland, M Clendenning, A Whelan, S Parry, J Arnold, V Vijay, N Atkinson, JL Hopper, AK Win, MA Jenkins, FA Macrae, IM Winship, C Rosty, DD Buchanan
BMC Gastroenterology | BMC | Published : 2022
Abstract
Objective: The unknown aetiology of Serrated Polyposis Syndrome (SPS) impedes risk prediction and prevention. We investigated risk factors for SPS, overall and stratified by World Health Organization (WHO)2010 clinical criteria and by colorectal cancer (CRC). Method: A retrospective case-control study involving a cross-sectional analysis from 350 unrelated individuals with SPS from the Genetics of Colonic Polyposis Study and 714 controls from the Australasian Colorectal Cancer Family Registry. Univariate and multivariate logistic regression modelling was used to determine the association between risk factors and SPS and risk factors associated with CRC in SPS. Results: Female biological sex ..
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Awarded by Victorian Centre for Biostatistics
Funding Acknowledgements
DDB is supported by a NHMRC Investigator grant (GNT1194896) and the University of Melbourne Dame Kate Campbell Fellowship. AKW is supported by NHMRC Investigator grant. MAJ is supported by NHMRC Leadership Investigator Fellowship. JCR is supported by a NHMRC Peter Doherty early career research fellowship (APP1120081). E. Milanzi is funded by the Victorian Centre for Biostatistics. Funding from the University of Melbourne awarded to DDB supported the design and conduct of the study, collection, management, analysis and interpretation of data. Collection and management of a subset of data reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number U01CA167551 and through cooperative agreements with the Australasian Colorectal Cancer Family Registry (NCI/NIH U01 CA074778 and U01/U24 CA097735). This research was performed under CCFR approved project C-AU-0506-02.